Adamts7 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 108153)
Source: NCBI Gene (ID 108153)
Symbol: Adamts7
Full name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Also known as: ADAM-TS7; ADAMTS7B
Summary: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent enzyme that degrades cartilage oligomeric matrix protein. The deficiency of the encoded protein decreases atherosclerosis in genetically hyperlipidemic mice and in response to vascular injury. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
Expression: Broad expression in limb E14.5 (RPKM 11.2), subcutaneous fat pad adult (RPKM 9.1) and 21 other tissues
Orthologs: human
Gene size: 40736bp
Exon count: 26