Full name: CD226 molecule

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DNAM-1; DNAM1; PTA1; TLiSA1

Summary: This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Expression: Broad expression in spleen (RPKM 2.4), lymph node (RPKM 1.3) and 15 other tissues

Gene size: 108500bp

Exon count: 10