Full name: calcium/calmodulin dependent protein kinase kinase 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CAMKK; CAMKKB

Summary: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]

Expression: Ubiquitous expression in brain (RPKM 24.4), spleen (RPKM 11.0) and 24 other tissues

Gene size: 60128bp

Exon count: 20