Full name: centromere protein F

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CENF; CILD31; PRO1779; STROMS; hcp-1

Summary: This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]

Expression: Broad expression in bone marrow (RPKM 9.7), testis (RPKM 6.0) and 15 other tissues

Gene size: 61377bp

Exon count: 21