Topors topoisomerase I binding, arginine/serine-rich [ Mus musculus (house mouse) ] - Gene - Data resources

106021

Topors topoisomerase I binding, arginine/serine-rich [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 106021)

Symbol: Topors

Full name: topoisomerase I binding, arginine/serine-rich

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: LUN; TP53BPL; p53BP3/LUN

Summary: Predicted to enable several functions, including DNA topoisomerase binding activity; antigen binding activity; and ubiquitin-like protein transferase activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of transcription, DNA-templated; and regulation of cell population proliferation. Located in ciliary basal body; nucleus; and photoreceptor connecting cilium. Is expressed in skin. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in CNS E11.5 (RPKM 10.1), placenta adult (RPKM 9.9) and 28 other tissues

Orthologs: human

Gene size: 10268bp

Exon count: 3