Full name: dynactin subunit 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DCTN50; DYNAMITIN; HEL-S-77; RBP50

Summary: This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

Expression: Ubiquitous expression in brain (RPKM 42.2), esophagus (RPKM 36.9) and 25 other tissues

Gene size: 17142bp

Exon count: 19