Tdp1 tyrosyl-DNA phosphodiesterase 1 [ Mus musculus (house mouse) ] - Gene - Data resources

104884

Tdp1 tyrosyl-DNA phosphodiesterase 1 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 104884)

Symbol: Tdp1

Full name: tyrosyl-DNA phosphodiesterase 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 2810481F14Rik; 4921509N21Rik; E430034L06Rik; Gm40556; MLZ-501; SCAN1

Summary: Predicted to enable 3'-tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding activity; and single-stranded DNA binding activity. Acts upstream of or within single strand break repair. Located in nucleus. Is expressed in ovary and testis. Used to study spinocerebellar ataxia type 1 with axonal neuropathy. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 1 with axonal neuropathy. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in testis adult (RPKM 14.7), CNS E14 (RPKM 6.9) and 22 other tissues

Orthologs: human

Gene size: 70716bp

Exon count: 22