Full name: glycoprotein nmb

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: HGFIN; NMB; PLCA3

Summary: The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Expression: Broad expression in skin (RPKM 225.4), gall bladder (RPKM 143.5) and 17 other tissues

Gene size: 28334bp

Exon count: 11