Full name: growth arrest specific 8

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Gas11

Summary: Enables microtubule binding activity and small GTPase binding activity. Involved in positive regulation of protein localization to cilium; positive regulation of smoothened signaling pathway; and regulation of microtubule binding activity. Acts upstream of or within several processes, including axoneme assembly; epithelial cilium movement involved in extracellular fluid movement; and flagellated sperm motility. Located in Golgi apparatus; ciliary basal body; and sperm flagellum. Is expressed in bronchus; nasal cavity epithelium; and nervous system. Used to study primary ciliary dyskinesia 33. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 33. Orthologous to human GAS8 (growth arrest specific 8). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in CNS E11.5 (RPKM 9.4), testis adult (RPKM 8.2) and 25 other tissues

Gene size: 17821bp

Exon count: 12