Full name: SEC24 homolog B, COPII coat complex component

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: SEC24

Summary: The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus. Mutations in this gene have been associated with neural tube defects, and are thought to be a result of a disruption in interactions with the protein encoded by the VANGL planar cell polarity protein 2 (VANGL2) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Expression: Ubiquitous expression in thyroid (RPKM 10.5), liver (RPKM 10.5) and 25 other tissues

Gene size: 107082bp

Exon count: 27