Full name: Sin3A associated protein 18

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: 2HOR0202; SAP18P

Summary: Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]

Expression: Ubiquitous expression in kidney (RPKM 50.6), brain (RPKM 39.3) and 25 other tissues

Gene size: 8979bp

Exon count: 5