Full name: dehydrogenase/reductase 9

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: 3-alpha-HSD; 3ALPHA-HSD; RDH-TBE; RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4; hRoDH-E2

Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Expression: Biased expression in colon (RPKM 23.4), esophagus (RPKM 9.8) and 12 other tissues

Gene size: 29091bp

Exon count: 8