Full name: poly(ADP-ribose) polymerase 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ADPRT2; ADPRTL2; ADPRTL3; ARTD2; PARP-2; pADPRT-2

Summary: This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in brain (RPKM 14.3), testis (RPKM 13.0) and 25 other tissues

Gene size: 14270bp

Exon count: 16