Full name: histone deacetylase 5

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: HD5; NY-CO-9

Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in skin (RPKM 14.0), ovary (RPKM 13.4) and 25 other tissues

Gene size: 46889bp

Exon count: 30