Project name: Single-Cell RNA-Seq Unveils Critical Regulators of Human FOXP3+ Regulatory T Cell Stability

Description: The heterogeneity and plasticity of T lymphocytes is critical for determining immune response outcomes. Functional regulatory T (Treg) cells are commonly characterized by stable FOXP3 expression and have reported to exhibit heterogeneous phenotypes under inflammatory conditions. Here, we performed single-cell RNA sequencing to investigate how human Treg cells respond to the pro-inflammatory cytokine IL-6. We observed that Treg cells divided into two subpopulations after IL-6 stimulation and implicated a previously unidentified regulator of Treg cells that may have target potential for application for biotherapies.

Data type: Raw sequence reads; Transcriptome or Gene expression

Sample scope: Monoisolate

Relevance: Medical

Release date: 2018-09-29

Last updated: 2018-10-11

Data size: 78.01GB