[Hepatocarcinogenesis in terms of HGF and its receptor].
Nihon Rinsho, 1993/2;51(2):380-5.
Kanda H[1], Kitagawa T
Affiliations
PMID: 8385239
Abstract
Hepatocyte growth factor (HGF) is a highly potent growth stimulator of hepatocytes and c-met proto-oncogene has recently been identified as its high-affinity receptor. Since the c-met gene expression is found in many types of cells, carcinogenic and/or transforming activity through autocline or paracline mechanism of HGF-c-met/HGFR system has become point of interest. By transfecting HGF into a unique immortalized mouse hepatocytes (MLE-10), which expresses c-met at high level, we were able to first demonstrate transforming activity of HGF by autocline mechanism.
MeSH terms
Animals; Carcinoma, Hepatocellular; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Male; Mice; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; Proto-Oncogenes; Rats; Receptors, Cell Surface; Transfection; Transformation, Genetic; Tumor Cells, Cultured
More resources
EndNote: Download