[Age related alterations of motor behavior and release of dopaminergic supersensitivity in rats].
Acta Biol Med Ger, 1981;40(12):1737-43.
PMID: 6285650
Abstract
Rats aged greater than or equal to 18 months show, aside from clearly diminished motor parameters (exploratory behavior, resting activity, nocturnal activity profile, rotation behavior), after intracerebral dopamine injection a considerably lower apomorphine hypermotility than young animals. The characteristic alteration of activity occurring in young rats during and following chronic administration of haloperidol (1 mg/kg . day, s.c. for 21 days) as an expression of developing dopaminergic supersensitivity does not appear in older animals. Repeated application of amphetamine (2 X 2 mg/kg daily) caused a significant increase in hypermotility. The results are interpreted as the consequence of a age-related reduction of the activity of central-dopaminergic transmission systems and are discussed with regard to possible differences in the realization of agonist- or antagonist-induced supersensitivity.
MeSH terms
Age Factors; Amphetamine; Animals; Dopamine; Drug Hypersensitivity; Haloperidol; Male; Motor Activity; Rats; Rats, Inbred Strains; Synaptic Transmission
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