Instantaneous Colorimetric and Fluorogenic Detection of Phosgene with a meso-Oxime-BODIPY.
Anal Chem, 2017/12/05;89(23):12837-12842.
Kim TI[1], Hwang B[1], Bouffard J[2], Kim Y[1]
Affiliations
PMID: 29137453DOI: 10.1021/acs.analchem.7b03316
Impact factor: 8.008
Abstract
The meso-oxime-substituted-1,3,5,7-tetramethyl BODIPY (1-oxime) was developed into a colorimetric and fluorogenic probe to selectively detect and quantify phosgene. The fast (<10 s) and sensitive (LOD = 0.09 ppb) phosgene detection is achieved by the conversion of the meso-oxime to the meso-nitrile, resulting in a large fluorescence turn-on response. The utility of 1-oxime was established for the visual detection of phosgene in solution and in a practical solid-state platform, making it a suitable candidate for on-site monitoring of phosgene gas exposure in the workplace.
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