ERBB2 775insYVMA

Variant type

missense mutation

Location

Chromosome 17

Exon

8

Protein change

p.775insYVMA

cDNA change

-

Genomic coordinate

Chromosome 17

FATHMM prediction

-

Variant category

I

Variant description

The A775insYVMA mutation is a in-frame insertion occurring within exon 20 of HER2, which is on the COOH-terminal side of the C-helix. This mutation leads to oncogenic transformation in a cellular assay (PMID: 23610105).

Variant frequence

This section displays the distribution of mutated samples and tissue types (top 5).

Accoiciated drug