BRIP1

Official symbol

BRIP1

Official full name

BRCA1 interacting protein C-terminal helicase 1

Gene ID

83990

Gene type

-

Other name

BACH1,FANCJ,OF

Gene location

Gene introduction

BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is a gene that encodes a protein that functions in normal double-strand break repair of BRCA1.

Cancer pathway

The main pathways: The cell signaling pathways that are involved in DNA damage are displayed. Excision repair cross-complementation group genes (ERCC-1/-4), X-ray repair complementing defective repair in Chinese hamster cells genes (XRCC-1/-5/-6), poly(ADP-ribose) polymerase 1 (PARP1), the Fanconi anemia gene complex (FANC-A/-C/-D2/-E/-F/-G/-L), Rad51 recombinase (RAD51), ATM serine/threonine kinase (ATM), ATR serine/threonine kinase (ATR), protein kinase, DNA-activated catalytic polypeptide (PRKDC), and the breast cancer, early onset genes (BRCA1/2) are included in the DNA damage pathway. Specific nodes in the pathway that are therapeutically actionable are noted. Click here to open a larger version of this image in a new window.

Related to cancer

Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

Alteration in cancer

Related drugs in cancer