RET

Official symbol

RET

Official full name

ret proto-oncogene

Gene ID

5979

Gene type

-

Other name

CDHF12,CDHR16,HSCR1,MEN2A,MEN2B,MTC1,PTC,RET-ELE1

Gene location

Gene introduction

The RET gene, located on chromosome 10, encodes a receptor tyrosine kinase (RTK) belonging to the RET family of RTKs. This gene plays a crucial role in neural crest development. Binding of its ligands, the glial cell line derived neurotrophic factor (GDNF) family of extracellular signaling molecules , induces receptor phosphorylation and activation. Activated RET then phosphorylates its substrates, resulting in activation of multiple downstream cellular pathways.

Cancer pathway

The main pathways: Schematic of the RET signaling pathway. RET activation involves binding of glial cell line derived neurotrophic factor (GDNF)-family ligands as well as interaction with GFR alpha receptors, resulting in activation of intracellular MAPK and PI3K pathways. The letter "K" within the schema denotes the tyrosine kinase domain.

Related to cancer

Genomic alterations in RET are found in several different types of cancer. Activating point mutations in RET can give rise to the hereditary cancer syndrome, multiple endocrine neoplasia 2. Somatic point mutations in RET are also associated with sporadic medullary thyroid cancer Oncogenic kinase fusions involving the RET gene are found in ~1% of non-small cell lung cancers .

Alteration in cancer

Related drugs in cancer