Expression data from control and BCL11B-/- hESC-derived striatal medium spiny neurons and cortical glutamatergic neurons
Source: NCBI BioProject (ID PRJNA767962)
Source: NCBI BioProject (ID PRJNA767962)
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Project name: Homo sapiens
Description: Overall design: BCL11B knock-out hESC line was generated using the CRISPR/Cas9-assisted genome editing technology with guide RNAs targeting exon 2 of the BCL11B gene. To investigate whether BCL11B deficiency affects the homeostasis and function of human striatal and cortical neurons, we performed striatal and cortical neural differentiation on the BCL11B-/- line along with the isogenic control HUES9 iCas9 cells using an established protocol (Arber et al., Development 2015). Total mRNA from control and BCL11B-/- neurons was collected and prepared for RNA-seq analysis at day 30 in vitro neural differentiation.
Data type: transcriptome
Sample scope: Multiisolate
Relevance: Medical
Organization: Cardiff University
Last updated: 2021-10-02