Project name: Transcriptomic analysis of gene profile in KSHV+ PEL cells changed by bacterial quorum sensing molecules [BCBL_OdDHL]

Description: KSHV-related primary effusion lymphoma is mostly seen in immunocompromised individuals such as HIV+ patients, who frequently suffering polymicrobial infections including different opportunistic pathogens. It is interesting to explore the host gene profile in PEL altered by bacterial quorum sensing molecules, the key systems regulating virulence factors in many bacteria.Overall design: BCBL-1 were incubated with 25μM of OdDHL from P. aeruginosa for 48 h, then the HumanHT-12 v4 Expression BeadChip (Illumina) was used to detect gene profile altered within OdDHL treated PEL when compared to vehicle-treated cells.

Data type: Transcriptome or Gene expression

Sample scope: Multiisolate

Relevance: Medical

Last updated: 2018-02-05