Project name: Transcriptomic analysis of microglia from 7 week Npc1 disease mouse model treated or not with 4000mg.kg-1 HPBCD

Description: the study aims to describe the modifications occurring the microglia isolated from NPC1 disease mouse model using a transcriptomic and phenotypic approach. The analysis is also performed on animal treated with the reference drug HPBCD, currently under clinical trial in human.Overall design: FACS isolated cell from Npc1 KO and WT mice were harvested from 7-week-old animals treated with HPBCD (n=3/genotype) or vehicle (n=3/ genotype) or no treatment (n=5/ genotype). Transcriptome was analyzed for modified signaling pathway further validated by additional experiments.

Data type: Transcriptome or Gene expression

Sample scope: Multiisolate

Relevance: ModelOrganism

Last updated: 2018-01-11