H3K79me2 ChIP-seq in cerebellar granular neurons (CGN) and progenitors (CGNP) upon DOT1L inhibition with SGC0946 in vitro
Source: NCBI BioProject (ID PRJNA395990)
Source: NCBI BioProject (ID PRJNA395990)
0 0
Project name: Mus musculus
Description: DOT1L as methyltransferase of H3K79 is implicated in brian development. Here, we further defined DOT1L function within the granular neurons during cerebellar development using ChIP-seq of H3K79 dimethylation of isolated cerebellar granular neurons and progenitors. Thereby we compared samples treated with a DOT1L inhibitor versus DMSO treated cells. The data sets reveals new important targets of DOT1L, which ensure a correct development of the cerebellum.Overall design: H3K79me2 ChIP-seq of CGNPs,4 h after DOT1L inhibition and CGNs, 44 h after DOT1L inhibition; compared to DMSO control each. Cells derived from murine cerebellum of P7 NMRI WT mice
Data type: Epigenomics
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: Vogel, Department of Molecular Embryology, Albert-Ludwigs University Freiburg, Institute of Anatomy and Cell Biology
Literatures
- PMID: 30302725
Last updated: 2017-07-27