Project name: Homo sapiens

Description: Maps of open chromatin in three primary human blood cell types of the myeloid lineage (megakaryocytes, erythroblasts and monocytes) using the formaldehyde-assisted isolation of regulatory elements method followed by next-generation sequencing (FAIRE-seq). We also generated FAIRE-seq data in the megakaryocytic cell line CHRF-288-11. In addition to our data sets, we retrieved FAIRE-seq data for the erythroblastoid cell line K562 (ENCODE Project Consortium 2012) and pancreatic islets (Gaulton et al. 2010), and reanalyzed these data sets using the same methodology.Overall design: Genome-wide open chromatin profiles of megakaryocytes, erythroblasts and monocytes (in each 2 individuals), pancreatic islets (1 individual), CHRF 288-11 megakaryocytic cells (2 samples) and K562 erythroblastoid cells (2 samples).

Data type: Epigenomics

Sample scope: Multiisolate

Relevance: Medical

Last updated: 2012-05-10