HnRNP L is important for the expression of oncogene SRSF3 and oncogenic potential of oral squamous cell carcinoma cells.
Sci Rep, 2016/11/03;6:35976.
Jia R[1], Zhang S[1], Liu M[1], Zhang Y[1], Liu Y[2], Fan M[1], Guo J[1]
Affiliations
PMID: 27808105DOI: 10.1038/srep35976
Impact factor: 4.996
Abstract
Oral squamous cell carcinoma (OSCC) is the leading cause of death related to oral diseases. The mechanisms of OSCC development remain largely unknown. Heterogeneous nuclear ribonucleoprotein L (HnRNP L) is a multi-functional splicing factor. It has been reported to be an important regulator of apoptosis. However, the functions of hnRNP L in cancer need to be further explored. In the present study, we found that OSCC tissues expressed significantly higher levels of hnRNP L than normal tissues. Depletion of hnRNP L retarded cell growth, cell migration, and tumorigenesis of OSCC cells. HnRNP L regulates both the expression of oncogenic splicing factor SRSF3 and the alternative splicing of SRSF3 exon 4. Expression of hnRNP L is correlated with SRSF3 expression in OSCC tissues. These findings suggest that hnRNP L is important for the pathogenesis of OSCC and may be a novel potential therapeutic target of OSCC.
MeSH terms
Alternative Splicing; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cell Cycle; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Heterogeneous-Nuclear Ribonucleoprotein L; Humans; Mice; Mice, Nude; Mouth Neoplasms; Oncogenes; Prognosis; Serine-Arginine Splicing Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays
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