Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate.
Nat Med, 2016/11;22(11):1256-1259.
Adams Waldorf KM[1], Stencel-Baerenwald JE[2, 3], Kapur RP[4, 5], Studholme C[6, 7, 8], Boldenow E[6, 9], Vornhagen J[9, 10], Baldessari A[11], Dighe MK[8], Thiel J[8], Merillat S[9], Armistead B[9, 10], Tisoncik-Go J[2, 3], Green RR[2, 3], Davis MA[2, 3], Dewey EC[2, 3], Fairgrieve MR[2, 3], Gatenby JC[8], Richards T[8], Garden GA[4, 12], Diamond MS[13, 14, 15, 16], Juul SE[6], Grant RF[11], Kuller L[11], Shaw DW[8, 17], Ogle J[11], Gough GM[11], Lee W[11], English C[11], Hevner RF[18, 19], Dobyns WB[6, 19], Gale M Jr[2, 3], Rajagopal L[6, 9, 10]
Affiliations
PMID: 27618651DOI: 10.1038/nm.4193
Impact factor: 87.241
Abstract
We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.
MeSH terms
Animals; Aspartic Acid; Brain; Choline; Creatine; Echoencephalography; Female; Fetus; Glutamic Acid; Glutamine; Inositol; Macaca nemestrina; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Pregnancy; Pregnancy Complications, Infectious; RNA, Viral; Ultrasonography, Prenatal; Zika Virus; Zika Virus Infection
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