The reference genome sequence of Saccharomyces cerevisiae: then and now.
G3 (Bethesda), 2014/3/20;4(3):389-98.
Engel SR[1], Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM
Affiliations
PMID: 24374639DOI: 10.1534/g3.113.008995
Impact factor: 3.542
Abstract
The genome of the budding yeast Saccharomyces cerevisiae was the first completely sequenced from a eukaryote. It was released in 1996 as the work of a worldwide effort of hundreds of researchers. In the time since, the yeast genome has been intensively studied by geneticists, molecular biologists, and computational scientists all over the world. Maintenance and annotation of the genome sequence have long been provided by the Saccharomyces Genome Database, one of the original model organism databases. To deepen our understanding of the eukaryotic genome, the S. cerevisiae strain S288C reference genome sequence was updated recently in its first major update since 1996. The new version, called "S288C 2010," was determined from a single yeast colony using modern sequencing technologies and serves as the anchor for further innovations in yeast genomic science.
Keywords: S288C; Saccharomyces cerevisiae; genome release; model organism; reference sequence
MeSH terms
Chromosome Mapping; Databases, Factual; Genome, Fungal; Internet; Open Reading Frames; Saccharomyces cerevisiae; Sequence Analysis, DNA; User-Computer Interface
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