Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes.
Epigenetics, 2014/2;9(2):186-93.
Klein BJ[1], Lalonde ME[2], Côté J[2], Yang XJ[3], Kutateladze TG[1]
Affiliations
PMID: 24169304DOI: 10.4161/epi.26792
Impact factor: 4.861
Abstract
The MOZ/MORF complexes represent an example of a chromatin-binding assembly whose recruitment to specific genomic regions and activity can be fine-tuned by posttranslational modifications of histones. Here we detail the structures and biological functions of epigenetic readers present in the four core subunits of the MOZ/MORF complexes, highlight the imperative role of combinatorial readout by the multiple readers, and discuss new research directions to advance our understanding of histone acetylation.
Keywords: BRPF; ING5; KAT6A; KAT6B; MORF; MOZ; PHD; acetylation; histone; reader
MeSH terms
Acetylation; Animals; Epigenesis, Genetic; Histone Acetyltransferases; Humans; Nuclear Proteins; Protein Conformation; Protein Multimerization; Protein Subunits; Zinc Fingers
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