Relations between the effects of histamine, pheniramin and metiamide on spontaneous motility and the formation of cyclic AMP in the isolated rat uterus.
Naunyn Schmiedebergs Arch Pharmacol, 1975;287(3):321-7.
Mitznegg P, Schubert E, Fuchs W
PMID: 239354
Impact factor: 3.195
Abstract
Histamine (5 X 10(-6) to 10(-3) M) depressed the spontaneous motility of the isolated rat uterus in a dose-dependent manner. Under these conditions uterine cyclic AMP was raised up to 92%. Both effects, uterine relaxation and cyclic AMP accumulation after 2 min could be inhibited dose dependently by the H2-antihistaminic compound metiamide (1.7 X 10(-6) M to 1.7 X 10(-4) M). By contrast, the H1-antagonist pheniramin (4.4 X 10(-5) M) was ineffective. It was concluded that the histamine-induced inhibition of rat uterine motility is mediated by cyclic AMP which is formed in response to stimulation of H2-histaminergic receptors.
MeSH terms
Animals; Cyclic AMP; Female; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Metiamide; Pheniramine; Rats; Receptors, Drug; Thiourea; Uterine Contraction; Uterus
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