Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.
J Clin Invest, 2013/2;123(2):903-7.
Klatt NR[1], Canary LA, Sun X, Vinton CL, Funderburg NT, Morcock DR, Quiñones M, Deming CB, Perkins M, Hazuda DJ, Miller MD, Lederman MM, Segre JA, Lifson JD, Haddad EK, Estes JD, Brenchley JM
Affiliations
PMID: 23321668
Impact factor: 19.456
Abstract
HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4+ T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.
MeSH terms
Adjuvants, Immunologic; Animals; Anti-Retroviral Agents; CD4-Positive T-Lymphocytes; Combined Modality Therapy; Dietary Supplements; Disease Models, Animal; Gastrointestinal Tract; HIV Infections; Humans; Macaca nemestrina; Prebiotics; Probiotics; Simian Acquired Immunodeficiency Syndrome; Transcriptome
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