The pharmacokinetics and metabolism of meloxicam in camels after intravenous administration.
J Vet Pharmacol Ther, 2012/4;35(2):155-62.
Wasfi IA[1], Al Ali WA, Agha BA, Kamel AM, Al Biriki NA, Al Neaimi KM
Affiliations
PMID: 21635268DOI: 10.1111/j.1365-2885.2011.01312.x
Impact factor: 1.567
Abstract
The pharmacokinetics and metabolism of meloxicam was studied in camels (Camelus dromedarus) (n = 6) following intravenous (i.v.) administration of a dose of 0.6 mg·kg/body weight. The results obtained (mean ± SD) were as follows: the terminal elimination half-life (t(1/2β) ) was 40.2 ± 16.8 h and total body clearance (Cl(T) ) was 1.94 ± 0.66 mL·kg/h. The volume of distribution at steady state (V(SS)) was 92.8 ± 13.7 mL/kg. One metabolite of meloxicam was tentatively identified as methylhydroxy meloxicam. Meloxicam and metabolite were excreted unconjugated in urine. Meloxicam could be detected in plasma 10 days following i.v. administration in camels using a sensitive liquid chromatography tandem mass spectrometry (LC/MS/MS) method.
MeSH terms
Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Camelus; Chromatography, Liquid; Drug Residues; Half-Life; Injections, Intravenous; Male; Meloxicam; Tandem Mass Spectrometry; Thiazines; Thiazoles
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