Full name: oxysterol binding protein like 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DFNA67; DNFA67; ORP-2; ORP2

Summary: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014]

Expression: Ubiquitous expression in skin (RPKM 12.0), esophagus (RPKM 9.6) and 25 other tissues

Gene size: 57663bp

Exon count: 15