Full name: oxysterol binding protein 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 1700095P05Rik; C630001G20Rik; Gm244; ORP-4; OSBPL1

Summary: The protein encoded by this gene belongs to the oxysterol-binding protein-related family of proteins, which are defined by a C-terminal sterol domain with a highly conserved EQVSHHPP motif. Oxysterols are oxygenated derivatives of cholesterol that are involved in mechanisms that include apoptosis, cholesterol homeostasis, lipid trafficking and cell differentiation. This protein is selectively expressed at high levels in the brain and testis. Within the testis, the mRNA is localized to postmeiotic germ cells, including spermatids and spermatozoa, but is not detectable in somatic cells. Mice homozygous mutant for a targeted deletion in this gene do not exhibit overt developmental phenotypes but are male sterile. Females display normal fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Expression: Biased expression in testis adult (RPKM 125.0), cortex adult (RPKM 12.5) and 2 other tissues

Gene size: 160270bp

Exon count: 21