Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 66442)
Source: NCBI Gene (ID 66442)
Symbol: Spc25
Full name: SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Also known as: 2600017H08Rik; 2610205L13Rik; Spbc25
Summary: This gene encodes a component of the kinetochore-associated NDC80 protein complex, which is required for the mitotic spindle checkpoint and for microtubule-kinetochore attachment. During meiosis in mouse, the protein localizes to the germinal vesicle and then is associated with the chromosomes following germinal vesicle breakdown. Knockdown of this gene in oocytes results in precocious polar body extrusion, chromosome misalignment and aberrant spindle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression: Biased expression in liver E14 (RPKM 25.3), CNS E11.5 (RPKM 24.7) and 10 other tissues
Orthologs: human
Gene size: 26831bp
Exon count: 9