Full name: trans-acting transcription factor 4

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 5730497N03Rik; HF-1b; HF1-b

Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within regulation of heart contraction. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in congenital heart disease and dilated cardiomyopathy. Orthologous to human SP4 (Sp4 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in whole brain E14.5 (RPKM 2.8), CNS E14 (RPKM 2.6) and 23 other tissues

Gene size: 69791bp

Exon count: 6