Full name: laminin, alpha 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 5830440B04; dy; mKIAA4087; mer; merosin

Summary: Predicted to be an extracellular matrix structural constituent. Acts upstream of or within axon guidance and positive regulation of cholinergic synaptic transmission. Located in several cellular components, including neuromuscular junction; sarcolemma; and synaptic cleft. Is expressed in several structures, including alimentary system; basement membrane; metanephros; musculature; and skin. Used to study congenital merosin-deficient muscular dystrophy 1A. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in bladder adult (RPKM 7.3), heart adult (RPKM 7.3) and 22 other tissues

Gene size: 635741bp

Exon count: 66