Hlcs holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 110948)
Source: NCBI Gene (ID 110948)
Symbol: Hlcs
Full name: holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: 410I21.SP6; D16Jhu34
Summary: Predicted to enable biotin binding activity; biotin-protein ligase activity; and enzyme binding activity. Predicted to be involved in histone biotinylation and response to biotin. Located in mitochondrion. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 3.4), ovary adult (RPKM 3.1) and 28 other tissues
Orthologs: human
Gene size: 186045bp
Exon count: 16