Children 's Cancer Database was established to research and improve treatments for children with cancer. Cancer is the second leading cause of death (following accidents) in children aged 0 to 14 years. The most common types of cancer diagnosed in children ages 0 to 14 years are leukemias and pediatric brain tumors. In the last 40 years, the overall survival rate for children’s cancer has increased from 10% to nearly 90%. DNA and other tissue samples from childhood cancer patients which collected from Beijing Tiantan Hospital and then sequenced in BGI. This database is a collection of genotype and phenotype information data to research the childhood cancer. The application of next-generation sequencing to analysis of childhood cancer can provide an unprecedented understanding of their molecular biology and clinically relevant alterations.