Introduction

Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females worldwide, accounting for 23% (1.38 million) of the total new cancer cases and 14% (458,400) of the total cancer deaths in 2008 (Jemal et al. 2011; Jemal, Siegel, and Ward 2010). In the U.S., 249,260 new cases and 40,890 deaths are estimated for 2016 (ACS 2016). Traditionally, treatment decisions have been based on tumor histology and the status of three main biomarkers: ER (estrogen receptor 1, or ESR1), PR (progesterone receptor, or PGR), and HER2 (erb-b2 receptor tyrosine kinase 2, or ERBB2, also known as neu). Despite significant improvements in the treatment of breast cancer, new therapies and treatment strategies are needed.
Balko, J., I. Mayer, M. Levy, C. Arteaga. 2016. Molecular Profiling of Breast Cancer. My Cancer Genome

Guideline

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Case

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External Links

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Research Progress

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Curated Knowledge

The below lists the genes that has strong relation to breast cancer.
Related references and evidence are provided.The badge shows that how many papers, studies, and other resources support the conclusion of the relationship.

No data available.

Statistics in Database

In this database, the most frequently mutated genes and most affected donors are below.

Most Frequently Mutated Genes

SymbolNameLocationLocus typeVariationsDonors affected
breast cancerAll tumour type
SymbolNameLocationLocus typeVariationsbreast cancerAll tumour type

Statistics

Most Affected Donors

IDGenderAgePrimary siteVariationsAffected genes
IDGenderAgePrimary siteVariationsAffected genes