Introduction

Colorectal cancer is the second leading cause of cancer related mortality in the United States, with an estimated 134,490 new cases and 49,190 deaths anticipated in 2016 (ACS 2016​). With the advent of more chemotherapy options and with the availability of biologic therapies in the recent past, mortality rates are declining, and patients are living longer. Over the past 20 years, survival in metastatic colorectal cancer has more than doubled. Nonetheless, colorectal cancer remains the second leading cause of cancer related death in the United States. New therapeutic strategies are clearly needed.
The main histologic subtype of colorectal cancer is adenocarcinoma. Colorectal adenocarcinomas arise through the acquisition of a series of mutations that occur over the space of many years, and results in the evolution of normal epithelium to adenoma to carcinoma to metastasis (Fearon and Vogelstein 1990). In the past two decades, there has been increasing recognition that some somatic mutations may be prognostic or predictive markers for specific therapies available in colorectal cancer. These mutations involve genes such as KR​AS, BRAF, PIK3CA, AKT1, SMAD4, PTEN, NRAS, and TGFBR2 (Baba et al. 2011; De Roock et al. 2010; Dienstmann et al. 2011; Fernandez-Peralta et al. 2005; Haigis et al. 2008; Negri et al. 2010; Papageorgis et al. 2011; Sartore-Bianchi et al. 2009). Furthermore, there has been increasing recognition that some of these mutant gene products may be targets for drug development. (De Roock et al. 2010; Huang et al. 2008; Thenappan et al. 2009).
Chan, E. 2016. Molecular Profiling of Colorectal Cancer. My Cancer Genome

Guideline

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Case

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External Links

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Research Progress

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Curated Knowledge

The below lists the genes that has strong relation to colorectal cancer.
Related references and evidence are provided.The badge shows that how many papers, studies, and other resources support the conclusion of the relationship.

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Statistics in Database

In this database, the most frequently mutated genes and most affected donors are below.

Most Frequently Mutated Genes

SymbolNameLocationLocus typeVariationsDonors affected
colorectal cancerAll tumour type
SymbolNameLocationLocus typeVariationscolorectal cancerAll tumour type

Statistics

Most Affected Donors

IDGenderAgePrimary siteVariationsAffected genes
IDGenderAgePrimary siteVariationsAffected genes