Human cancer cell lines have long served as tools for cancer research and oncology drug discovery, but whether they harbor heterogeneity and how intra-cell-line heterogeneity affect biomedical studies remains elusive. Here, we generated single-cell transcriptomic and single-cell chromatin accessibility data of dozens of cancer cell lines and 2 normal cell lines to illustrate both transcriptomic and epigenetic heterogeneity within different cell lines.

scRNA

Search for gene expression in each cell line.

scATAC

Search for gene expression in each cell line.

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We provided our processed data available for the research community.

How to cite

Zhu, Q., Zhao, X., Zhang, Y. et al. Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines. Nat Commun 14, 8170 (2023). 10.1038/s41467-023-43991-9