Spatially resolved transcriptomics and beyond.
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IF: 59.581
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Cited by: 359
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Abstract

Considerable progress in sequencing technologies makes it now possible to study the genomic and transcriptomic landscape of single cells. However, to better understand the complexity of multicellular organisms, we must devise ways to perform high-throughput measurements while preserving spatial information about the tissue context or subcellular localization of analysed nucleic acids. In this Innovation article, we summarize pioneering technologies that enable spatially resolved transcriptomics and discuss how these methods have the potential to extend beyond transcriptomics to encompass spatially resolved genomics, proteomics and possibly other omic disciplines.

Keywords

IMC
LCM-seq
Spatial Transcriptomics
Tomo-seq
ISS
smFISH
MIBI
TIVA
Spatial Genomics
FISSEQ

MeSH terms

Gene Expression Profiling
High-Throughput Screening Assays
Molecular Imaging
Sequence Analysis
Single-Cell Analysis
Spatial Analysis

Authors

Crosetto, Nicola
Bienko, Magda
van Oudenaarden, Alexander

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