Genetics of subthalamic nucleus in development and disease.
Exp Neurol, 2005/4;192(2):320-30.
Philips ST[1], Albin RL, Martin DM
Affiliations
PMID: 15755549
Impact factor: 5.62
Abstract
The subthalamic nucleus (STN) is a crucial node in the basal ganglia. Clinical success in targeting the STN for deep brain stimulation in Parkinson's disease patients has prompted increased interest in understanding STN biology. In this report, we discuss recent evidence for transcription factor mediated regulation of STN development. We also review STN developmental neurobiology and known patterns of gene expression in the developing and mature STN.
MeSH terms
Animals; Brain Diseases; Gene Expression; Gene Expression Regulation, Developmental; Humans; Neural Networks, Computer; Neural Pathways; Neurons; Subthalamic Nucleus; Transcription Factors
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