PMID- 34751943 OWN - NLM STAT- Publisher TI - Integrative oncology: Addressing the global challenges of cancer prevention and treatment. CI - © 2021 The Authors. CA: A Cancer Journal for Clinicians published by Wiley Periodicals LLC on behalf of American Cancer Society. LA - eng PT - Journal Article PT - Review PL - United States TA - Ca Cancer J Clin JT - CA: a cancer journal for clinicians JID - 0370647 IS - 1542-4863 (Electronic) LID - 10.3322/caac.21706 [doi] FAU - Mao, Jun J AU - Mao JJ AUID- ORCID: https://orcid.org/0000-0001-9229-0380 AD - Bendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, New York, New York. FAU - Pillai, Geetha Gopalakrishna AU - Pillai GG AD - Traditional, Complementary and Integrative Medicine Unit, Service Delivery and Safety Department, World Health Organization, Geneva, Switzerland. FAU - Andrade, Carlos Jose AU - Andrade CJ AD - Brazilian National Cancer Institute, Rio de Janeiro, Brazil. FAU - Ligibel, Jennifer A AU - Ligibel JA AD - Leonard P. Zakim Center for Integrative Therapies and Healthy Living, Dana-Farber Cancer Institute, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts. FAU - Basu, Partha AU - Basu P AD - International Agency for Research on Cancer, World Health Organization, Lyon, France. FAU - Cohen, Lorenzo AU - Cohen L AD - Integrative Medicine Program, Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Khan, Ikhlas A AU - Khan IA AD - National Center for Natural Products Research, University of Mississippi, Jackson, Mississippi. FAU - Mustian, Karen M AU - Mustian KM AD - Wilmot Cancer Institute, Department of Surgery, University of Rochester Medical Center, Rochester, New York. FAU - Puthiyedath, Rammanohar AU - Puthiyedath R AD - Amrita Vishwa Vidyapeetham University, Amritapuri, Kerala, India. FAU - Dhiman, Kartar Singh AU - Dhiman KS AD - Central Council for Research in Ayurvedic Sciences, New Delhi, India. FAU - Lao, Lixing AU - Lao L AD - Virginia University of Integrative Medicine, Fairfax, Virginia. FAU - Ghelman, Ricardo AU - Ghelman R AD - Brazilian Academic Consortium for Integrative Health, University of São Paulo, São Paulo, Brazil. FAU - Cáceres Guido, Paulo AU - Cáceres Guido P AUID- ORCID: https://orcid.org/0000-0002-9747-4960 AD - Pharmacokinetics and Research in Clinical Pharmacology and Integrative Medicine Group, Garrahan Pediatric Hospital, Buenos Aires, Argentina. AD - Traditional, Complementary, and Integrative Medicine Network of the Americas, São Paulo, Brazil. FAU - Lopez, Gabriel AU - Lopez G AD - Integrative Medicine Program, Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. FAU - Gallego-Perez, Daniel F AU - Gallego-Perez DF AD - Traditional, Complementary, and Integrative Medicine Network of the Americas, São Paulo, Brazil. AD - Boston University School of Public Health, Boston, Massachusetts. FAU - Salicrup, Luis Alejandro AU - Salicrup LA AD - Center for Global Health and Office of Cancer Complementary and Alternative Medicine, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Maryland. IS - 0007-9235 (Linking) SB - IM OTO - NOTNLM OT - alternative OT - and integrative medicine OT - cancer prevention OT - complementary OT - global health OT - health policy OT - survivorship LR - 20211109 DP - 2021 Nov 09 DEP - 20211109 AB - The increase in cancer incidence and mortality is challenging current cancer care delivery globally, disproportionally affecting low- and middle-income countries (LMICs) when it comes to receiving evidence-based cancer prevention, treatment, and palliative and survivorship care. Patients in LMICs often rely on traditional, complementary, and integrative medicine (TCIM) that is more familiar, less costly, and widely available. However, spheres of influence and tensions between conventional medicine and TCIM can further disrupt efforts in evidence-based cancer care. Integrative oncology provides a framework to research and integrate safe, effective TCIM alongside conventional cancer treatment and can help bridge health care gaps in delivering evidence-informed, patient-centered care. This growing field uses lifestyle modifications, mind and body therapies (eg, acupuncture, massage, meditation, and yoga), and natural products to improve symptom management and quality of life among patients with cancer. On the basis of this review of the global challenges of cancer control and the current status of integrative oncology, the authors recommend: 1) educating and integrating TCIM providers into the cancer control workforce to promote risk reduction and culturally salient healthy life styles; 2) developing and testing TCIM interventions to address cancer symptoms or treatment-related adverse effects (eg, pain, insomnia, fatigue); and 3) disseminating and implementing evidence-based TCIM interventions as part of comprehensive palliative and survivorship care so patients from all cultures can live with or beyond cancer with respect, dignity, and vitality. With conventional medicine and TCIM united under a cohesive framework, integrative oncology may provide citizens of the world with access to safe, effective, evidence-informed, and culturally sensitive cancer care.