PMID- 34067701 OWN - NLM STAT- PubMed-not-MEDLINE VI - 13 IP - 10 TI - Mapping of Metabolic Heterogeneity of Glioma Using MR-Spectroscopy. LA - eng PT - Journal Article PL - Switzerland TA - Cancers (basel) JT - Cancers JID - 101526829 IS - 2072-6694 (Print) LID - 2417 [pii] LID - 10.3390/cancers13102417 [doi] FAU - Franco, Pamela AU - Franco P AUID- ORCID: 0000-0002-7954-2974 AD - Department of Neurosurgery, Medical Center-University of Freiburg, 79106 Freiburg, Germany. AD - Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. FAU - Huebschle, Irene AU - Huebschle I AD - Department of Neurosurgery, Medical Center-University of Freiburg, 79106 Freiburg, Germany. AD - Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. FAU - Simon-Gabriel, Carl Philipp AU - Simon-Gabriel CP AUID- ORCID: 0000-0003-3746-1372 AD - Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. AD - Department of Radiology, Medical Center-University of Freiburg, 79106 Freiburg, Germany. FAU - Dacca, Karam AU - Dacca K AD - Department of Neurosurgery, Medical Center-University of Freiburg, 79106 Freiburg, Germany. AD - Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. FAU - Schnell, Oliver AU - Schnell O AD - Department of Neurosurgery, Medical Center-University of Freiburg, 79106 Freiburg, Germany. AD - Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. FAU - Beck, Juergen AU - Beck J AD - Department of Neurosurgery, Medical Center-University of Freiburg, 79106 Freiburg, Germany. AD - Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. FAU - Mast, Hansjoerg AU - Mast H AD - Department of Neuroradiology, Medical Center-University of Freiburg, 79106 Freiburg, Germany. FAU - Urbach, Horst AU - Urbach H AD - Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. AD - Department of Neuroradiology, Medical Center-University of Freiburg, 79106 Freiburg, Germany. FAU - Wuertemberger, Urs AU - Wuertemberger U AD - Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. AD - Department of Neuroradiology, Medical Center-University of Freiburg, 79106 Freiburg, Germany. FAU - Prinz, Marco AU - Prinz M AD - Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. AD - Institute of Neuropathology, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. AD - Signaling Research Centers BIOSS and CIBSS, University of Freiburg, 79106 Freiburg, Germany. AD - Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. FAU - Hosp, Jonas A AU - Hosp JA AUID- ORCID: 0000-0001-7696-9334 AD - Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. AD - Department of Neurology and Neuroscience, Medical Center-University of Freiburg, 79106 Freiburg, Germany. FAU - Delev, Daniel AU - Delev D AD - Department of Neurosurgery, RWTH University of Aachen, 52074 Aachen, Germany. FAU - Mader, Irina AU - Mader I AD - Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. AD - Department of Neuroradiology, Medical Center-University of Freiburg, 79106 Freiburg, Germany. AD - Specialist Centre for Radiology, Schoen Clinic, 83569 Vogtareuth, Germany. FAU - Heiland, Dieter Henrik AU - Heiland DH AUID- ORCID: 0000-0002-9258-3033 AD - Department of Neurosurgery, Medical Center-University of Freiburg, 79106 Freiburg, Germany. AD - Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany. AD - Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, 79106 Freiburg, Germany. IS - 2072-6694 (Linking) OTO - NOTNLM OT - 1H-MRS OT - MR spectroscopy OT - MRS OT - chemical shift imaging OT - glioma OT - magnetic resonance spectroscopy OT - neurooncology OT - neuroradiology OT - neurosurgery OT - radiomics PMC - PMC8155922 LR - 20210605 DP - 2021 May 17 DEP - 20210517 AB - Proton magnetic resonance spectroscopy (1H-MRS) delivers information about the non-invasive metabolic landscape of brain pathologies. 1H-MRS is used in clinical setting in addition to MRI for diagnostic, prognostic and treatment response assessments, but the use of this radiological tool is not entirely widespread. The importance of developing automated analysis tools for 1H-MRS lies in the possibility of a straightforward application and simplified interpretation of metabolic and genetic data that allow for incorporation into the daily practice of a broad audience. Here, we report a prospective clinical imaging trial (DRKS00019855) which aimed to develop a novel MR-spectroscopy-based algorithm for in-depth characterization of brain lesions and prediction of molecular traits. Dimensional reduction of metabolic profiles demonstrated distinct patterns throughout pathologies. We combined a deep autoencoder and multi-layer linear discriminant models for voxel-wise prediction of the molecular profile based on MRS imaging. Molecular subtypes were predicted by an overall accuracy of 91.2% using a classifier score. Our study indicates a first step into combining the metabolic and molecular traits of lesions for advancing the pre-operative diagnostic workup of brain tumors and improve personalized tumor treatment.