PMID- 30527911 OWN - NLM STAT- MEDLINE VI - 49 IP - 6 TI - Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. PG - 1175-1190.e7 CI - Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Immunity JT - Immunity JID - 9432918 IS - 1097-4180 (Electronic) LID - S1074-7613(18)30448-5 [pii] LID - 10.1016/j.immuni.2018.10.007 [doi] FAU - He, Wenyan AU - He W AD - Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany. FAU - Holtkamp, Stephan AU - Holtkamp S AD - Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany. FAU - Hergenhan, Sophia Martina AU - Hergenhan SM AD - Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany. FAU - Kraus, Kerstin AU - Kraus K AD - Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany. FAU - de Juan, Alba AU - de Juan A AD - Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany. FAU - Weber, Jasmin AU - Weber J AD - Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany. FAU - Bradfield, Paul AU - Bradfield P AD - Mesenflow Technologies SARL, Fondation Eclosion, Geneva, Switzerland. FAU - Grenier, Julien Martin Pierre AU - Grenier JMP AD - Aix-Marseille University, Centre National de la Recherche Scientifique, INSERM, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, Marseille, France. FAU - Pelletier, Jeoffrey AU - Pelletier J AD - Aix-Marseille University, Centre National de la Recherche Scientifique, INSERM, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, Marseille, France. FAU - Druzd, David AU - Druzd D AD - Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany. FAU - Chen, Chien-Sin AU - Chen CS AD - Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany. FAU - Ince, Louise Madeleine AU - Ince LM AD - Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany; Department of Pathology and Immunology, Centre Médical Universitaire, University of Geneva, Switzerland. FAU - Bierschenk, Susanne AU - Bierschenk S AD - Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany. FAU - Pick, Robert AU - Pick R AD - Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany. FAU - Sperandio, Markus AU - Sperandio M AD - Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. FAU - Aurrand-Lions, Michel AU - Aurrand-Lions M AD - Aix-Marseille University, Centre National de la Recherche Scientifique, INSERM, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, Marseille, France. FAU - Scheiermann, Christoph AU - Scheiermann C AD - Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig Maximilians University of Munich, BioMedical Centre, 82152 Planegg-Martinsried, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Department of Pathology and Immunology, Centre Médical Universitaire, University of Geneva, Switzerland. Electronic address: christoph.scheiermann@med.uni-muenchen.de. IS - 1074-7613 (Linking) RN - 0 (Cell Adhesion Molecules) RN - 0 (Transcription Factors) SB - IM MH - Adult MH - Animals MH - Cell Adhesion Molecules/genetics/immunology/metabolism MH - Cell Movement/genetics/*immunology MH - Circadian Rhythm/*immunology MH - Endothelial Cells/immunology/metabolism MH - Female MH - Gene Expression Profiling MH - Gene Expression Regulation/*immunology MH - Homeostasis/genetics/immunology MH - Humans MH - Leukocytes/cytology/*immunology/metabolism MH - Male MH - Mice, Inbred C57BL MH - Mice, Knockout MH - Mice, Transgenic MH - Middle Aged MH - Organ Specificity/genetics/immunology MH - Transcription Factors/genetics/*immunology/metabolism OTO - NOTNLM OT - *circadian OT - *immunology OT - *leukocyte OT - *migration PMC - PMC6303219 DCOM- 20190528 LR - 20210927 DP - 20181218 DEP - 20181204 AB - The number of leukocytes present in circulation varies throughout the day, reflecting bone marrow output and emigration from blood into tissues. Using an organism-wide circadian screening approach, we detected oscillations in pro-migratory factors that were distinct for specific vascular beds and individual leukocyte subsets. This rhythmic molecular signature governed time-of-day-dependent homing behavior of leukocyte subsets to specific organs. Ablation of BMAL1, a transcription factor central to circadian clock function, in endothelial cells or leukocyte subsets demonstrated that rhythmic recruitment is dependent on both microenvironmental and cell-autonomous oscillations. These oscillatory patterns defined leukocyte trafficking in both homeostasis and inflammation and determined detectable tumor burden in blood cancer models. Rhythms in the expression of pro-migratory factors and migration capacities were preserved in human primary leukocytes. The definition of spatial and temporal expression profiles of pro-migratory factors guiding leukocyte migration patterns to organs provides a resource for the further study of the impact of circadian rhythms in immunity.