PMID- 27159897 OWN - NLM STAT- MEDLINE VI - 16 IP - 11-12 TI - Imaging mass spectrometry: Molecular microscopy for the new age of biology and medicine. PG - 1607-12 CI - © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. LA - eng PT - Journal Article PT - Research Support, N.I.H., Extramural PL - Germany TA - Proteomics JT - Proteomics JID - 101092707 IS - 1615-9861 (Electronic) LID - 10.1002/pmic.201600133 [doi] FAU - Caprioli, Richard M AU - Caprioli RM AD - Department of Biochemistry, Vanderbilt University, Nashville, TN, USA. AD - Department of Chemistry, Vanderbilt University, Nashville, TN, USA. AD - Department of Pharmacology, Vanderbilt University, Nashville, TN, USA. AD - Department of Medicine, Vanderbilt University, Nashville, TN, USA. IS - 1615-9853 (Linking) RN - 0 (Antibodies) SB - IM MH - Antibodies/*genetics/isolation & purification MH - Humans MH - Mass Spectrometry/*methods MH - Molecular Imaging/*methods MH - Proteomics/*methods OTO - NOTNLM OT - *Image fusion OT - *Molecular analysis OT - *Technology OT - *Tissue imaging mass spectrometry PMC - PMC6197803 DCOM- 20171003 LR - 20181113 DP - 201606 DEP - 20160527 AB - Imaging mass spectrometry provides a powerful tool for monitoring and discovery of molecular processes in the spatial domain in tissues for research and practical applications in both biology and medicine. This technology directly measures molecular compounds in tissues without the use of target-specific reagents such as antibodies, is applicable to a wide variety of analytes, and can provide spatial resolutions below the single cell level. Importantly, it has paradigm shifting capabilities in clinical applications, especially for anatomic pathology.