PMID- 21630385 OWN - NLM STAT- MEDLINE VI - 46 IP - 6 TI - High spatial resolution imaging mass spectrometry and classical histology on a single tissue section. PG - 568-71 CI - Copyright © 2011 John Wiley & Sons, Ltd. LA - eng PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - England TA - J Mass Spectrom JT - Journal of mass spectrometry : JMS JID - 9504818 IS - 1096-9888 (Electronic) LID - 10.1002/jms.1926 [doi] FAU - Deutskens, Fabian AU - Deutskens F AD - Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA. FAU - Yang, Junhai AU - Yang J FAU - Caprioli, Richard M AU - Caprioli RM IS - 1076-5174 (Linking) RN - 0 (Nerve Tissue Proteins) SB - IM MH - Animals MH - Cerebellum/chemistry MH - Female MH - Histocytochemistry/*methods MH - Histocytological Preparation Techniques MH - Male MH - Molecular Imaging/*methods MH - Nerve Tissue Proteins/analysis/*chemistry MH - Rats MH - Rats, Sprague-Dawley MH - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods PMC - PMC3118566 DCOM- 20110916 LR - 20211020 DP - 2011 Jun AB - The work presented in this report describes and demonstrates a protocol for protein imaging analysis of biological tissue using MALDI IMS where histological staining and MS analysis are performed on the same tissue section. Spatial image resolution is shown at 35 µm for sagittal sections of the cerebellum from rat brain.